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Adrenal glands failing to generate enough cortisol and aldosterone causes Addison's disease, also known as primary adrenal insufficiency, an uncommon condition. Often caused by autoimmune destruction of the adrenal glands, TB, or hereditary elements, this disorder is While aldosterone helps preserve blood pressure and electrolyte balance, cortisol is vital for controlling metabolism, stress response, and immune system activity.
Gradually developing symptoms of Addison's disease include chronic fatigue, inadvertent weight loss, muscle weakness, low blood pressure, salt cravings, and darkening of the skin (hyperpigmentation). People may also get nausea, vomiting, stomach discomfort, vertigo, and mood disorders, including irritability or depression. Severe occurrences of an adrenal crisis can cause life-threatening symptoms, including shock, disorientation, and extreme dehydration.
Diagnosis consists of imaging of the adrenal glands, an ACTH stimulation test, and blood tests measuring cortisol and ACTH levels. To bring hormonal equilibrium, treatment consists of lifelong hormone replacement with corticosteroids such as hydrocortisone or fludrocortisone. Effective illness care depends on keeping a healthy diet, controlling stress, and spotting early symptoms of adrenal crisis. Prevention of problems and guarantees of a good quality of life for affected people depend on prompt medical attention.