Paget

Paget's Disease: Abnormal Bone Remodelling Causes Misshapen Bones
Paget's disease of the bone is a chronic condition that impairs the normal process of bone remodelling, in which old bone tissue is replaced with new. This disturbance results in deformed, swollen, and structurally weak bones. While it can affect any bone, it most usually affects the pelvis, spine, skull, and long bones in the legs.
Although the precise aetiology of Paget's disease remains unknown, it is believed that genetic and environmental factors, such as specific viral infections, play a role. Men tend to be slightly more affected than women, and the condition typically develops in older age. Many people with Paget's disease are asymptomatic, but some develop bone discomfort, deformities, fractures, or joint problems. In severe situations, the condition can cause consequences such as hearing loss (if the skull is affected) or nerve compression.
The diagnostic process commonly uses X-rays, blood tests (to measure alkaline phosphatase levels), and bone scans. Treatment tries to alleviate symptoms and slow disease development, with bisphosphonates being used to regulate bone remodelling. In rare situations, patients may require pain treatment drugs and surgery.
Early detection and treatments are critical for controlling Paget's illness and reducing its impact on quality of life. Regular check-ups and a healthy lifestyle also promote bone health.